Scancell presentará en la reunión anual de la AACR de 2024
02 de abril de 2024
Scancell Holdings plc
("Scancell" o la "Compañía")
Scancell to Present at 2024 AACR Annual Meeting
Scancell Holdings plc (AIM: SCLP), the developer of novel immunotherapies for the treatment of cancer, today announces that Professor Lindy Durrant will be presenting at American Association for Cancer Research (AACR) Annual Meeting, taking place in San Diego, California on 5-10 April 2024.
Scancell will present data on its open-label Phase 2 SCOPE trial, investigating its cancer vaccine, SCIB1, in combination with checkpoint inhibitors (CPIs) in advanced melanoma. SCIB1 previously demonstrated an 85% response rate among 13 first-line advanced melanoma patients.
The AACR conference is an internationally recognized annual meeting, serving as a focal point of the cancer research community where the latest advances in the cancer space can be shared amongst world leading experts. Scancell is presenting as part of the 'Cancer Vaccines: Ready for Prime Time?' clinical trials symposium, covering progress from a number of innovative clinical stage cancer vaccines, including follow up data from the BioNTech mRNA vaccine.
Detalles de presentación:
Título: A DNA plasmid melanoma cancer vaccine, SCIB1, combined with nivolumab + ipilimumab in patients with advanced unresectable melanoma: Efficacy and safety results from the open-label Phase 2 SCOPE Trial
Sesión: CTMS01 - Cancer Vaccines: Ready for Prime Time?
Fecha y hora de la sesión: Sunday 7 April 2024, 3:50 PM - 4:00 PM PST
Ubicación: Ballroom 20 AB - Upper Level - Convention Center
Published Abstract Number: CT024
Ponente: Professor Lindy Durrant, Chief Executive Officer and Chief Scientific Officer
Autores: H. Shaw, P. Patel, M. Payne, S. Kumar, M. Highley, K. Prasad, R. Board, C. Barlow, S. Danson, R. Miller, G. Goodhew, F. Master, L. Durrant
-FIN-
Para más información, por favor póngase en contacto con: | |
Scancell Holdings plc | +44 0 20 3709 5700 |
Profesora Lindy Durrant, directora ejecutiva Dr. Jean-Michel Cosséry, presidente no ejecutivo
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Stifel Nicolaus Europa limitada (Asesor designado y conjunto Broker) | +44 0 20 7710 7600 |
Nicholas Moore / Samira Essebiyea (Banca de inversión en atención médica) |
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Nick Adams/Nick Harland (corretaje corporativo)
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WG Partners LLP (Conjunto Broker) | +44 0 20 3705 9330 |
David Wilson/Claes Spang/Sathesh Nadarajah/Erland Sternby
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Panmure Gordon (Reino Unido) Limited (Articulación Broker) | +44 0 20 7886 2500 |
Freddy Crossley / Emma Earl (Finanzas corporativas) |
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Rupert Dearden (Corretaje corporativo) |
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Consejo ICR | +44 0 20 3709 5700 |
Mary-Jane Elliott/Angela Gray/Lindsey Neville |
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Acerca del ensayo clínico SCOPE Fase 2
SCOPE is an open label, multicohort, multicentre, Phase 2 study of SCIB1 in patients with advanced unresectable melanoma receiving either nivolumab with ipilimumab or pembrolizumab. SCIB1 is a deoxyribonucleic acid (DNA) plasmid vaccine encoding two CD8 epitopes from the melanoma antigens tyrosinase-related protein-2 and glycoprotein 100 (gp100), plus two CD4 epitopes from gp100. The purpose of the study is to determine whether the addition of SCIB1 to standard of care CPIs can improve the objective response rate (ORR) of patients with advanced melanoma relative to the CPIs alone. The ORR is defined as the proportion of patients with a complete or partial response at any time after the start of treatment. During the first stage of the SCOPE trial reported here, patients received SCIB1 in combination with the best treatment currently available, namely the CPIs nivolumab and ipilimumab. The First Stage milestone was designed to demonstrate at least a 70% ORR with an 80% power i.e. at least 9/15 patients responding, assessed by radiological imaging. Further information relating to the clinical trial can be found on the Company's website at https://www.scancell.co.uk y en https://classic.clinicaltrials.gov/ct2/show/NCT04079166
Sobre Scancell
Scancell is a clinical stage biopharmaceutical company that is leveraging its proprietary research, built up over many years of studying the human adaptive immune system, to generate novel medicines to treat significant unmet needs in cancer. The Company is building a pipeline of innovative products by utilising its four technology platforms: Moditope® e ImmunoBody® para vacunas y GlyMab® y AvidiMab® para anticuerpos.
Las respuestas inmunitarias adaptativas incluyen anticuerpos y células T (CD4 y CD8), que pueden reconocer células dañadas o infectadas. Para destruir dichas células cancerosas o infectadas, Scancell utiliza vacunas para inducir respuestas inmunitarias o anticuerpos monoclonales (mAb) para redirigir las células inmunitarias o los fármacos. El enfoque único de la Compañía es que sus productos innovadores apuntan a modificaciones de proteínas y lípidos. Para las vacunas (Moditope® e ImmunoBody®) esto incluye la citrulinación y la homocitrulación de proteínas, mientras que su cartera de mAb se dirige a los glicanos o azúcares que se agregan a las proteínas y/o lípidos (GlyMab®) o mejora la potencia de los anticuerpos y su capacidad para destruir directamente las células tumorales (AvidiMab®).
Para obtener más información sobre Scancell, visite: https://www.scancell.co.uk/
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